Upgrade from ECC5.0 to ECC6.0

Dear Expert,

Currently I am running ECC5.0 (EA_APPL SP14) and use IHS(Atrion) as content (Compliance Engine).  I am planning to upgrade to ECC6.0 EHP7 and will still use IHS as content.  I just wonder is any big difference between those two versions? My company is only using Product Safety.

Thanks.